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July 8, 2026JAMA Network OpenOpen Access

Prefrontal Transcranial Pulse Stimulation for Major Depressive Disorder

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Authors

PQPenny Ping QinMJMinxia JinRKRebecca Laidi Kan

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Overview

Randomized trial demonstrates antidepressant effects in individuals with major depressive disorder, suggesting potential benefits of this novel treatment.

Key Points

  • To examine the antidepressant efficacy of transcranial pulse stimulation in individuals with major depressive disorder.
  • Randomized double-blind sham-controlled trial with 80 participants
  • Participants received 12 sessions of either active or sham stimulation over 4 weeks
  • Main outcome measured was change in Montgomery-Åsberg Depression Rating Scale score after treatment sessions.
  • Active group showed a greater reduction in scores from Montgomery-Åsberg Depression Rating Scale (mean difference -4.19; P = .048)
  • Functional connectivity improved significantly in active group compared to sham within key brain areas
  • Results support the safety and tolerability of the transcranial pulse stimulation treatment.

Cite This Study

Qin et al. (2026) studied this question.

synapsesocial.com/papers/6a4de8ebd2ea289ef628369bhttps://doi.org/10.1001/jamanetworkopen.2026.21592
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antidepressant effect of transcranial pulse stimulation (TPS) targeting neuropsychiatric disorders: a retrospective analysis.2026 · 1 citations
  2. 2Multi-voxel pattern analysis for characterizing functional connectivity and neurocognitive function in major depression: A CAN-BIND-1 report2025
  3. 3Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease2025 · 27 citations
  4. 4Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial2021 · 802 citations
  5. 5Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression—A Pilot Randomized Controlled Trial2023 · 49 citations