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July 8, 2026The Annual Review of Pharmacology and Toxicology

Proteome-Wide Binding Affinity Profiling

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Authors

NYNoah YardenyJGJacob B. Geri

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Overview

Review of affinity profiling technologies measuring binding interactions in proteins, highlighting their biological significance.

Key Points

  • This work aims to review methods for measuring ligand-protein binding affinities across the proteome.
  • Review of protein stability–based methods for detecting ligand-induced stabilization.
  • Examination of proteolytic resistance–based methods to infer protein binding.
  • Analysis of techniques using derivatized probes for enriching ligand-protein complexes.
  • Proteome-wide binding affinity profiles can be achieved through novel methods.
  • Ligand-induced stabilization and proteolytic resistance offer insights into binding interactions.
  • Derivatized probes enhance the capture of ligand-protein complexes, improving analysis precision.

Cite This Study

Yardeny et al. (2026) studied this question.

synapsesocial.com/papers/6a4de9e4d2ea289ef6283defhttps://doi.org/10.1146/annurev-pharmtox-060225-120320
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