Key result
The mathematical formulation of venous return describes how intravascular volume distributes among compliant compartments based on flow-dependent pressures, rather than mean systemic pressure driving flow.
Why the study?
Guyton's concepts of venous return and mean systemic pressure (Pms) are widely accepted and sought clinically, but some concepts are inconsistent with elementary physical principles.
This review clarifies that the classic Guytonian model of venous return describes volume distribution among compliant compartments rather than mean systemic pressure physically driving venous return.
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Challenges traditional venous return models; leaves open whether compartment-based views alter clinical volume management.
G. L. Brengelmann (2019) conducted a review in Venous return and hemodynamics. The mathematical formulation of venous return describes how intravascular volume distributes among compliant compartments based on flow-dependent pressures, rather than mean systemic pressure driving flow.
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