Key result
Intracoronary nitroglycerin resolves severe refractory coronary vasospasm and restores TIMI III flow in AMI.
Why the study?
Refractory coronary artery spasm is a challenging condition with many complications, including acute myocardial infarction, and is relatively less documented in women and within the South Bronx population.
Case Report (n=1)
No
Refractory coronary artery spasm can present as acute myocardial infarction and rapidly progress to cardiogenic shock, requiring prompt recognition and aggressive management with intracoronary vasodilators and hemodynamic support.
Answers are grounded in this paper and cite their sources.
Refractory spasm with shock warrants close arrhythmia monitoring; leaves open optimal support strategies in this rare scenario.
Refractory coronary artery spasm is a challenging condition with many complications, including acute myocardial infarction. We present the case of an elderly woman who developed refractory coronary artery vasospasm requiring extensive hemodynamic support. She had an abnormal electrocardiogram. She was diagnosed with severe coronary artery vasospasm that initially responded to intracoronary nitroglycerin. However, the course was complicated by arrhythmias and cardiogenic shock following an additional episode of vasospasm that required higher concentrations of nitroglycerin. Notably, this case is relatively less documented in women and within the South Bronx population. Refractory coronary artery spasm is a critical condition that can lead to life-threatening outcomes. Prompt and effective treatment is essential, especially for high-risk patients, to prevent cardiac ischemia. Given the significant dangers of delayed or insufficient treatment, it is crucial to manage coronary artery spasms proactively to enhance patient outcomes and avoid severe complications. In addition, this diagnosis should be strongly considered in women, with an emphasis on following guidelines for managing cases of acute myocardial infarction.
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Javed et al. (2025) conducted a case report in Refractory coronary artery vasospasm (n=1). Intracoronary nitroglycerin was evaluated on Resolution of coronary vasospasm and restoration of TIMI III flow. Intracoronary administration of of nitroglycerin successfully resolved severe, diffuse refractory coronary vasospasm and restored TIMI III flow in a 78-year-old woman presenting with acute myocardial infarction.
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