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July 9, 2026Annals of the ICRP

Intermediate risk factors in ionising radiation cataractogenesis

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Authors

KNK. NeriishiRRR.B. Richardson

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Overview

Randomized trial evaluates cataract risk from ionising radiation in A-bomb survivors and astronauts, suggesting new mechanisms.

Key Points

  • To explore intermediate risk factors involved in cataract formation due to low-dose ionising radiation.
  • Analyzed existing data from A-bomb survivors and astronauts regarding cataract development and related biochemical factors.
  • Assessed relationships between oxidative stress, inflammation, and cataractogenesis in irradiated individuals.
  • Investigated serum biomarkers associated with cataracts in the context of ionising radiation exposure.
  • Persistent inflammation and elevated calcium levels were found to be statistically significant factors in the development of PSC and cortical cataracts.
  • Intermediate variables such as insulin resistance were linked to increased cataractogenic risk.
  • Findings support the hypothesis that oxidative stress and changes in ocular ion balance contribute to cataract formation.

Cite This Study

Neriishi et al. (2026) studied this question.

synapsesocial.com/papers/6a4f3ad62b81a944af574f72https://doi.org/10.1177/01466453251412608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionizing Radiation-induced Lens Injury: Epidemiology, Dose-effect Relationship, and Molecular Mechanisms2026
  2. 2Non-cancer effects of radiation exposure: Cataracts, diseases of the circulatory system, and beyond2026
  3. 3Space Radiation Effects on the Glutathione Redox Cycle and Cataract Formation2026 · 1 citations
  4. 4The Essence of Radiogenic Damages in the Lens: Threshold, Tissue Reactions (Deterministic Effects), but not Stochastic, Non-Threshold Effects2024
  5. 5Cataract Review of Integrating Pathogenic Mechanisms, Experimental Models, and Therapeutic Development2025