What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure (n=278). Intervention: GNRI-defined nutritional risk (GNRI < 98) vs. No nutritional risk (GNRI ≥ 98). Primary outcome: In-hospital mortality (p=<0.001).

What does this research mean for the field?

In patients hospitalized with heart failure, a lower Geriatric Nutritional Risk Index (GNRI) is associated with a higher prevalence of diabetes mellitus and greater clinical vulnerability, although its association with in-hospital mortality is not independent of heart failure severity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the relationship between nutritional risk assessed by GNRI, diabetes mellitus prevalence, and in-hospital mortality in heart failure patients.

July 9, 2026NutrientsOpen Access

Reduced Geriatric Nutritional Risk Index Is Associated with Prevalent Diabetes Mellitus and In-Hospital Mortality in Patients Hospitalized with Heart Failure

Q: What are the key findings of this study?

GNRI-defined nutritional risk was associated with higher in-hospital mortality than no nutritional risk (29.1% vs. 10.6%, p<0.001), but this lost significance after adjusting for HF severity.

Q: What does this research mean for the field?

In patients hospitalized with heart failure, a lower Geriatric Nutritional Risk Index (GNRI) is associated with a higher prevalence of diabetes mellitus and greater clinical vulnerability, although its association with in-hospital mortality is not independent of heart failure severity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This study aims to evaluate the relationship between nutritional risk assessed by GNRI, diabetes mellitus prevalence, and in-hospital mortality in heart failure patients.

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Key result

GNRI-defined nutritional risk shows no independent link to in-hospital mortality after adjusting for HF severity.

P<0.001
n=278

Why the study?

The relationship between the Geriatric Nutritional Risk Index (GNRI), diabetes mellitus, and in-hospital mortality in hospitalized heart failure patients remained incompletely characterized.

Is GNRI-defined nutritional risk associated with prevalent diabetes mellitus and in-hospital mortality in patients hospitalized with heart failure?

Population

278 consecutive patients hospitalized with HF at a tertiary cardiology center

Comparison

GNRI-defined nutritional risk (GNRI < 98) vs no nutritional risk (GNRI ≥ 98)

Design

Prospective observational study

Authors

CNConstanta Corina Nitu VRVictoria Rus FRFlorina Ruţă

Discussion

Member takes

Overview

Nutritional risk screening may identify higher-mortality HF patients with diabetes; leaves open whether interventions improve outcomes.

Key Points

This study aims to evaluate the relationship between nutritional risk assessed by GNRI, diabetes mellitus prevalence, and in-hospital mortality in heart failure patients.
Prospective observational design including 278 patients hospitalized with heart failure.
Nutritional risk was assessed using GNRI, classifying patients into risk categories.
Logistic regression evaluated the link between GNRI and diabetes; Cox regression and Kaplan–Meier assessed in-hospital mortality.
42.1% of patients had GNRI-defined nutritional risk.
Patients with nutritional risk had a higher prevalence of diabetes (73.5% vs. 50.9%, p < 0.001) and longer hospital stays.
In-hospital mortality was almost three times higher in patients with nutritional risk (29.1% vs. 10.6%, p < 0.001).

Study Design

Type

Observational (n=278)

Multicenter

Structured PICO

Is GNRI-defined nutritional risk associated with prevalent diabetes mellitus and in-hospital mortality in patients hospitalized with heart failure?

Population

278 consecutive patients hospitalized with heart failure, assessed for nutritional risk during their hospital stay.

Exposure

GNRI-defined nutritional risk (GNRI < 98)

Comparator

No nutritional risk (GNRI ≥ 98)

Outcome

Prevalence of diabetes mellitus and in-hospital mortalityhard clinical

Main Result

Absolute Event Rate: 29.1% vs 10.6%

p-value: p=<0.001

Lower GNRI values identify heart failure patients with greater nutritional vulnerability, higher diabetes prevalence, and increased unadjusted in-hospital mortality.

Cite This Study

Nitu et al. (2026) conducted an observational in Heart failure (n=278). GNRI-defined nutritional risk (GNRI < 98) vs. No nutritional risk (GNRI ≥ 98) was evaluated on In-hospital mortality (p=<0.001). GNRI-defined nutritional risk was associated with higher in-hospital mortality than no nutritional risk (29.1% vs. 10.6%, p<0.001), but this lost significance after adjusting for HF severity.

synapsesocial.com/papers/6a4f3c8a2b81a944af575d88 https://doi.org/10.3390/nu18132198

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July 9, 2026NutrientsOpen Access

Reduced Geriatric Nutritional Risk Index Is Associated with Prevalent Diabetes Mellitus and In-Hospital Mortality in Patients Hospitalized with Heart Failure

View Full Paper

Ask AI

Bookmark

Key result

GNRI-defined nutritional risk shows no independent link to in-hospital mortality after adjusting for HF severity.

P<0.001
n=278

Why the study?

The relationship between the Geriatric Nutritional Risk Index (GNRI), diabetes mellitus, and in-hospital mortality in hospitalized heart failure patients remained incompletely characterized.

Is GNRI-defined nutritional risk associated with prevalent diabetes mellitus and in-hospital mortality in patients hospitalized with heart failure?

Population

278 consecutive patients hospitalized with HF at a tertiary cardiology center

Comparison

GNRI-defined nutritional risk (GNRI < 98) vs no nutritional risk (GNRI ≥ 98)

Design

Prospective observational study

Authors

CNConstanta Corina Nitu VRVictoria Rus FRFlorina Ruţă

Discussion

Member takes

Overview

Nutritional risk screening may identify higher-mortality HF patients with diabetes; leaves open whether interventions improve outcomes.

Key Points

This study aims to evaluate the relationship between nutritional risk assessed by GNRI, diabetes mellitus prevalence, and in-hospital mortality in heart failure patients.
Prospective observational design including 278 patients hospitalized with heart failure.
Nutritional risk was assessed using GNRI, classifying patients into risk categories.
Logistic regression evaluated the link between GNRI and diabetes; Cox regression and Kaplan–Meier assessed in-hospital mortality.
42.1% of patients had GNRI-defined nutritional risk.
Patients with nutritional risk had a higher prevalence of diabetes (73.5% vs. 50.9%, p < 0.001) and longer hospital stays.
In-hospital mortality was almost three times higher in patients with nutritional risk (29.1% vs. 10.6%, p < 0.001).

Study Design

Type

Observational (n=278)

Multicenter

Structured PICO

Is GNRI-defined nutritional risk associated with prevalent diabetes mellitus and in-hospital mortality in patients hospitalized with heart failure?

Population

278 consecutive patients hospitalized with heart failure, assessed for nutritional risk during their hospital stay.

Exposure

GNRI-defined nutritional risk (GNRI < 98)

Comparator

No nutritional risk (GNRI ≥ 98)

Outcome

Prevalence of diabetes mellitus and in-hospital mortalityhard clinical

Main Result

Absolute Event Rate: 29.1% vs 10.6%

p-value: p=<0.001

Lower GNRI values identify heart failure patients with greater nutritional vulnerability, higher diabetes prevalence, and increased unadjusted in-hospital mortality.

Cite This Study

synapsesocial.com/papers/6a4f3c8a2b81a944af575d88 https://doi.org/10.3390/nu18132198

Also Consider

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