Key result
Major and moderate risk Geriatric nutritional risk index (<92) was associated with an increased risk of all-cause mortality in elderly patients with heart failure (HR 1.59; 95% CI 1.37-1.85).
Why the study?
The Geriatric Nutritional Risk Index might predict all-cause mortality in patients with heart failure, but a systematic evaluation was needed.
Does a low Geriatric Nutritional Risk Index (GNRI) predict increased all-cause mortality in elderly patients with heart failure?
Meta-Analysis (n=7,659)
Does a low Geriatric Nutritional Risk Index (GNRI) predict increased all-cause mortality in elderly patients with heart failure?
A lower Geriatric Nutritional Risk Index (GNRI <98) is significantly associated with increased all-cause mortality in elderly patients with heart failure, highlighting its utility as a prognostic nutritional assessment tool.
Answers are grounded in this paper and cite their sources.
Supports GNRI screening for mortality risk stratification in HF; strengthens pooled evidence for nutritional assessment in practice and future trials.
OBJECTIVES: Geriatric nutritional risk index (GNRI) might predict the all-cause mortality in patients with heart failure (HF). We performed a meta-analysis to evaluate the correlation between GNRI and all-cause mortality in patients with HF. METHODS: We searched the PubMed, Medline, Cochrane Library, and Embase databases for clinical trials investigating the association between GNRI and all-cause mortality in patients with HF, having the primary endpoint as all-cause mortality. RESULTS: In total, nine studies involving 7,659 subjects were included in the systematic review and meta-analysis. The results indicated that major risk and moderate risk GNRI (GNRI<92) was associated with an increased risk of all-cause mortality in elderly patients with HF (hazard ratios [HR] 1.59, 95% confidence intervals [CI] 1.37-1.85). Low risk GNRI (GNRI<98) group predicted all-cause mortality in elderly HF patients (HR 1.56, 95%CI 1.12-2.18) when compared with the high GNRI value group. A subgroup analysis indicated that the relationship between GNRI and HF might differ based on the subtype of heart failure. CONCLUSIONS: GNRI is a simple and well-established nutritional assessment tool to predict all-cause mortality in patients with HF.
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Dong et al. (2021) conducted a meta-analysis in Heart failure (n=7,659). Geriatric nutritional risk index (GNRI) <92 vs. High GNRI value group was evaluated on All-cause mortality (HR 1.59, 95% CI 1.37-1.85). Major and moderate risk Geriatric nutritional risk index (<92) was associated with an increased risk of all-cause mortality in elderly patients with heart failure (HR 1.59; 95% CI 1.37-1.85).
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