Key result
Osteopathic manipulative treatment modulated the autonomic nervous system in patients with heart failure compared to sham (670 vs 775; 95% CI -98 to 3591; P=.001).
Why the study?
While osteopathic manipulative treatment modulates the vascular and autonomic nervous system in healthy volunteers, its acute and time-course effects in patients with an overactive autonomic nervous system remain unclear.
Does a single session of osteopathic manipulative treatment improve flow-mediated dilation and heart rate variability in patients with heart failure?
RCT (n=20)
Does a single session of osteopathic manipulative treatment improve flow-mediated dilation and heart rate variability in patients with heart failure?
Absolute Event Rate: 670% vs 775%
p-value: p=.001
OMT acutely enhances endothelial function and vagal tone in HF; extends healthy volunteer data but leaves clinical outcomes untested.
OBJECTIVE: The purposed of this study was to valuate the effect of osteopathic manipulative treatment (OMT) on flow-mediated dilation and heart rate variability of patients with heart failure. BACKGROUND: Osteopathic manipulative treatment modulates both the vascular and autonomic nervous system (ANS) in healthy volunteers. However, the acute and time-course effects of the OMT on patients with an overactive ANS remain unclear. METHODS: This randomized controlled trial study included 20 patients with heart failure aged 50 to 60 years, allocated to a single session of OMT (base of the skull, retromaxillary region, heart, and thoracic duct) or sham. Flow-mediated dilation (FMD) at the brachial artery, hemodynamic measures, and heart rate variability were assessed in 3 periods (baseline, immediately after the intervention, and after 15 minutes). Multivariate analysis of variance procedure was used to compare intervention and periods. RESULTS: ) = 670 vs 775, 95% CI: [-98, 3591]; P = .001), suggesting a time-course ANS modulation after OMT. CONCLUSIONS: Osteopathic manipulative treatment was effective at increasing brachial blood flow and stimulating the vagal system in patients with heart failure. Moreover, vascular changes seem to precede the autonomic modulation.
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Amatuzzi et al. (2021) conducted an RCT in heart failure (n=20). Osteopathic manipulative treatment vs. sham was evaluated on Flow-mediated dilation, hemodynamic measures, and heart rate variability (95% CI -98 to 3591, p=.001). Osteopathic manipulative treatment modulated the autonomic nervous system in patients with heart failure compared to sham (670 vs 775; 95% CI -98 to 3591; P=.001).
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