Key result
In anesthetized dogs, changes in left ventricular diastolic pressure and volume during acute coronary artery occlusion depended on baseline cardiac volume and the presence of the pericardium.
Why the study?
Does acute coronary artery occlusion alter left ventricular diastolic pressure-volume relations under varying loading conditions in anesthetized dogs?
Population
Open-chest anesthetized dogs (n = 18)
Comparison
Acute coronary artery occlusion produced by… vs Steady-state conditions before occlusion
Design
Preclinical
Authors
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Pericardial presence may modulate ischemic LV diastolic shifts by baseline volume; leaves open translation to human acute coronary syndromes.
Does acute coronary artery occlusion alter left ventricular diastolic pressure-volume relations under varying loading conditions in anesthetized dogs?
The study demonstrates that changes in left ventricular diastolic pressure and volume during acute coronary occlusion are highly dependent on baseline cardiac volume and the constraining effect of the pericardium.
Robert J. Applegate (1991) studied Acute coronary artery occlusion (n=18). Altered loading conditions (dextran infusion, vena caval occlusion) and pericardium removal vs. Baseline steady-state conditions was evaluated on Left ventricular diastolic pressure-volume relations (change in LVEDP and LVEDV). In anesthetized dogs, changes in left ventricular diastolic pressure and volume during acute coronary artery occlusion depended on baseline cardiac volume and the presence of the pericardium.
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