Key result
Topical application of 1% tropicamide to the posterior left atrium decreased vagal stimulation-induced atrial fibrillation inducibility by 92% (P<0.001).
Why the study?
Does targeted parasympathetic blockade with tropicamide in the posterior left atrium reduce vagal AF inducibility in a canine model?
Population
13 dogs
Comparison
Topical application of 1% tropicamide to the… vs Left cervical vagal stimulation alone
Design
Preclinical
Authors
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Does not support clinical use of targeted parasympathetic blockade in AF; leaves open its role in human substrate modification.
Does targeted parasympathetic blockade with tropicamide in the posterior left atrium reduce vagal AF inducibility in a canine model?
Effect estimate: 92% decrease
p-value: p=<0.001
Parasympathetic fibers and M2 receptors are preferentially located in the posterior left atrium, and targeted blockade with tropicamide significantly reduces vagal AF inducibility in a canine model.
Arora et al. (2007) studied Atrial fibrillation (n=13). Topical tropicamide to the posterior left atrium was evaluated on Atrial fibrillation inducibility (92% decrease, p=<0.001). Topical application of 1% tropicamide to the posterior left atrium decreased vagal stimulation-induced atrial fibrillation inducibility by 92% (P<0.001).
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