Key result
Local pharmacological denervation of the posterior left atrium with atropine significantly inhibited atrial fibrillation inducibility during vagal stimulation, reducing the cumulative window of vulnerability from 158 ms to 42 ms.
Why the study?
Does local pharmacological denervation of the posterior left atrium inhibit atrial fibrillation inducibility and electrical remodeling in a canine model?
Population
32 healthy adult male mongrel dogs weighing 19±5 kg
Comparison
Local pharmacological denervation of the… vs Baseline state, control group without drug…
Design
Preclinical
Follow-up
Up to 6 hours (acute experiment)
Authors
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Does not inform clinical practice; extends preclinical evidence for targeted posterior left atrial denervation in vagal AF.
Does local pharmacological denervation of the posterior left atrium inhibit atrial fibrillation inducibility and electrical remodeling in a canine model?
Absolute Event Rate: 42% vs 158%
p-value: p=<0.05
Selective pharmacological denervation of the posterior left atrium significantly inhibits atrial fibrillation inducibility and prevents rapid atrial pacing-induced electrical remodeling in a canine model.
Qin et al. (2017) studied Atrial fibrillation (n=32). Pharmacological denervation of posterior left atrium (atropine) vs. Vagal stimulation without atropine was evaluated on Cumulative window of vulnerability (ƐWOV) during vagal stimulation (p=<0.05). Local pharmacological denervation of the posterior left atrium with atropine significantly inhibited atrial fibrillation inducibility during vagal stimulation, reducing the cumulative window of vulnerability from 158 ms to 42 ms.
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