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July 10, 2026BiomedicinesOpen Access

The State of the Art on Management of Patients with Unresectable Liver Metastases from Colorectal Cancer

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Authors

MPMartim PortoBLBeatriz LucianoJSJoão Simões

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Overview

Review discusses current treatment strategies for unresectable liver metastases from colorectal cancer, suggesting a need for personalized approaches.

Key Points

  • This review aims to evaluate current management strategies for unresectable colorectal liver metastases and identify challenges in treatment.
  • Comprehensive literature review of management strategies for unresectable colorectal liver metastases.
  • Focus on systemic chemotherapy, intra-arterial therapies, and liver transplantation.
  • Analysis of recent studies on patient selection and treatment sequencing.
  • Systemic chemotherapy is vital for conversion to resectability or as palliative care.
  • Liver-directed therapies like transarterial chemoembolization show effective local disease control.
  • Recent studies indicate that selected patients receiving liver transplantation can achieve improved long-term survival.

Cite This Study

Porto et al. (2026) studied this question.

synapsesocial.com/papers/6a508c766eeac72a437a08edhttps://doi.org/10.3390/biomedicines14071527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liver Transplantation for Unresectable Colorectal Liver Metastases.2025 · 6 citations
  2. 2The evolving landscape of colorectal liver metastasis management: from resection to transplantation – a narrative review2026
  3. 3Integration of Radical Intent Treatment in Colorectal Liver Metastases2025
  4. 4Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature2024 · 9 citations
  5. 5Contemporary Surgical Management of Colorectal Liver Metastases2024 · 9 citations