January 1, 2015Journal of Cardiovascular Magnetic ResonanceOpen Access

Left atrial structure and functional quantitation using cardiovascular magnetic resonance and multimodality tissue tracking: validation and reproducibility assessment

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Cardiovascular disease and healthy volunteers (n=55). Intervention: Multimodality Tissue Tracking (MTT) vs. Manual delineation. Primary outcome: Left atrial maximal volume (Vmax) correlation between MTT and manual delineation (r = 0.98, p=<0.001).

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Key result

Multimodality Tissue Tracking (MTT) derived left atrial biplane volume showed excellent correlation with manual delineation (r=0.98, p<0.001) and required only half the analysis time.

Why the study?

Does Multimodality Tissue Tracking (MTT) accurately and reproducibly measure left atrial volume and function compared to manual delineation in patients undergoing cardiovascular magnetic resonance?

Study Design

Type

Observational (n=55)

Blinding

Single-blind

Multicenter

Yes

Structured PICO

Does Multimodality Tissue Tracking (MTT) accurately and reproducibly measure left atrial volume and function compared to manual delineation in patients undergoing cardiovascular magnetic resonance?

Population

55 adults aged 45-84 years from the MESA cohort, including both healthy individuals and those with prior cardiovascular events, underwent CMR to validate left atrial tracking.

Exposure

Semi-automated delineation using Multimodality Tissue Tracking (MTT) software for cardiovascular magnetic resonance (CMR) to assess left atrial volume and function.

Comparator

Manual delineation using QMass software and Simpson's method from short-axis slices.

Outcome

Accuracy (correlation and agreement) of LA biplane volume and function measured by MTT compared to manual delineation, and intra-/inter-reader and inter-study reproducibility (Intra-class correlation coefficient).surrogate

Main Result

Effect estimate: r = 0.98

Absolute Event Rate: 86.5% vs 84.4%

p-value: p=<0.001

Multimodality Tissue Tracking provides accurate and reproducible measurements of left atrial volume and function from CMR in about half the time of manual delineation, making it suitable for clinical and longitudinal use.

Limitations

Focus of CMR was LV images rather than LA images, resulting in some cases with poor LA image quality.
Relatively small number of subjects used for assessment of variability.
Focus of CMR was LV images resulting in some cases with poor LA image quality
Relatively small number of subjects used for assessment of variability

Discussion

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Implication

MTT supports efficient, reproducible LA assessment in CMR research; leaves open routine clinical adoption pending larger trials.

Cite This Study

Zareian et al. (2015) conducted an observational in Cardiovascular disease and healthy volunteers (n=55). Multimodality Tissue Tracking (MTT) vs. Manual delineation was evaluated on Left atrial maximal volume (Vmax) correlation between MTT and manual delineation (r = 0.98, p=<0.001). Multimodality Tissue Tracking (MTT) derived left atrial biplane volume showed excellent correlation with manual delineation (r=0.98, p<0.001) and required only half the analysis time.

synapsesocial.com/papers/6a519482ac10e4e6224a779d https://doi.org/10.1186/s12968-015-0152-y

Topics

Cardiac MRI

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Left atrial structure and functional quantitation using cardiovascular magnetic resonance and multimodality tissue tracking: validation and reproducibility assessment

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Topics

Left atrial structure and functional quantitation using cardiovascular magnetic resonance and multimodality tissue tracking: validation and reproducibility assessment

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider