Key result
Isovolumic loading with a latex balloon significantly increased the left ventricular weight of heterotopically transplanted rat hearts to 397 +/- 13 mg compared to unloaded hearts at 14 days.
Why the study?
Does left ventricular isovolumic balloon placement prevent atrophy in heterotopically transplanted rat hearts?
Does left ventricular isovolumic balloon placement prevent atrophy in heterotopically transplanted rat hearts?
Absolute Event Rate: 397% vs 226%
Isovolumic loading prevents atrophy and maintains protein synthesis and RNA content in heterotopically transplanted rat hearts, demonstrating the critical role of cardiac work in regulating cardiac growth.
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Supports mechanical loading to counter atrophy in experimental transplants; leaves open applicability to clinical heart transplantation.
Klein et al. (1991) studied Cardiac atrophy in heterotopically transplanted hearts. Left ventricular isovolumic balloon placement vs. Unloaded heart and sham-loaded transplants was evaluated on Left ventricular weight. Isovolumic loading with a latex balloon significantly increased the left ventricular weight of heterotopically transplanted rat hearts to 397 +/- 13 mg compared to unloaded hearts at 14 days.
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