Key result
Heterotopic cardiac allografts show ~73% greater heart weight versus in situ rat hearts, alongside decreased myosin.
Why the study?
The regulation of myocardial protein content and changes in myosin content and isoenzyme distribution in heterotopic cardiac allografts were not well characterized.
Population
Heterotopic rat heart allografts
Comparison
Allograft hearts vs in situ hearts
Design
Preclinical experimental study
Authors
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Rejecting allografts reduce myosin content and shift isoenzymes despite weight gain; leaves open relevance to human transplant function.
p-value: p=<0.01
Heterotopic cardiac allografts undergo a decrease in myosin content and a shift in myosin isoenzymes despite an increase in total heart weight likely due to rejection.
Klein et al. (1987) studied Heterotopic cardiac allograft. Heterotopic cardiac allograft vs. In situ hearts was evaluated on Total heart weight and protein content (p=<0.01). Heterotopic cardiac allografts in rats showed significantly greater total heart weight (816 vs 471 mg) and protein content (117 vs 90 mg, P<0.01) compared to in situ hearts, alongside decreased myosin.
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