Why the study?
Does mechanical unloading via nonworking heterotopic transplantation alter insulin responsiveness and glycogen metabolism in rat hearts?
Population
Rat heart model
Comparison
Nonworking heterotopic infrarenal… vs In situ working hearts of the same animals
Design
Preclinical
Follow-up
1 week
Authors
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May alter glycogen metabolism in unloaded rat hearts; hypothesis-generating for contractile work effects on insulin responsiveness in humans.
Does mechanical unloading via nonworking heterotopic transplantation alter insulin responsiveness and glycogen metabolism in rat hearts?
Mechanical unloading of the heart increases myocardial glycogen concentration and reduces insulin-stimulated glycogen synthesis, suggesting contractile work is necessary to maintain maximal insulin responsiveness.
McNulty et al. (1995) studied this question.
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