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July 11, 2026Contemporary Clinical Trials CommunicationsOpen Access

Massed prolonged exposure for posttraumatic stress disorder among individuals in comprehensive substance use treatment: Study protocol for a randomized controlled trial

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Authors

JGJordan A. GetteDHDenise A. HienSKShannon M Kehle-Forbes

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Overview

Randomized trial evaluates massed prolonged exposure effectiveness in individuals with co-occurring PTSD and substance use disorders, suggesting improved treatment integration.

Key Points

  • To investigate the efficacy of massed prolonged exposure in treating individuals with co-occurring PTSD and substance use disorders during substance use treatment.
  • Randomized controlled trial comparing massed prolonged exposure with trauma treatment as usual.
  • Participants include individuals with PTSD and substance use disorders in comprehensive residential and outpatient programs.
  • Qualitative methods will assess implementation barriers and facilitators of M-PE.
  • M-PE demonstrated comparable treatment outcomes to traditional prolonged exposure therapy.
  • Qualitative data revealed participant experiences and implementation challenges.
  • The study aims to identify effective integration strategies for PTSD treatment within substance use programs.

Cite This Study

Gette et al. (2026) studied this question.

synapsesocial.com/papers/6a51dce1c18d7f28ca4ffdf4https://doi.org/10.1016/j.conctc.2026.101668
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