What question did this study set out to answer?

To compare long-term major adverse cardiovascular and cerebrovascular event risk between adult-onset type 1 and type 2 diabetes.

Long-Term Major Adverse Cardiovascular and Cerebrovascular Event Risk in Adult-Onset Type 1 Versus Type 2 Diabetes: A Propensity-Matched Cohort Study

View Full Paper

Ask AI

Bookmark

Authors

Cohort study compares cardiovascular event risk in adult-onset type 1 and type 2 diabetes, suggesting lower risk for type 1.

To compare long-term major adverse cardiovascular and cerebrovascular event risk between adult-onset type 1 and type 2 diabetes.
Utilized a multi-center U.S. database (TriNetX) for analysis.
Performed 1:1 propensity-score matching between type 1 and type 2 diabetes cohorts based on demographics and comorbidities.
Followed adults diagnosed with T1DM or T2DM from 2005-2015 until 2025.
10-year MACCE incidence in type 1 diabetes was 5.2%; matched cohort showed risks of MACCE at 5.5% for T1DM vs. 11.3% for T2DM (RR 0.48; p < 0.001).
All-cause mortality in type 1 diabetes was 7.7% compared to 8.3% for type 2 diabetes (RR 0.92; p = 0.003).
In patients on antihyperglycemics, mortality was similar between T1DM and T2DM (7.0% vs. 6.5%; RR 1.07; p = 0.45).

Astavans et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark