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July 12, 2026Journal of Fish Biology

An integrated transcriptomic and metabolomic analysis reveals hepatic physiological responses of P erca fluviatilis to heat stress

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Authors

SCS T ChenYWYi-Xiang WangZZZhigang Zhao

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Overview

Randomized trial investigates hepatic responses to heat stress in Eurasian perch, indicating oxidative damage and metabolic disruption.

Key Points

  • This research aims to explore the physiological responses of Eurasian perch to heat stress using integrated transcriptomic and metabolomic approaches.
  • Eurasian perch exposed to control (18°C) and heat stress (25°C) conditions.
  • Liver transcriptomics and metabolomics analyses conducted alongside physiological and biochemical assessments.
  • Combined analysis identified differentially expressed genes and metabolites related to heat stress.
  • Heat stress resulted in 536 differentially expressed genes and 262 metabolites.
  • Significant reduction in catalase activity (p < 0.05) and increase in malondialdehyde content.
  • Hepatic oxidative damage, energy metabolism disturbances, and key signaling pathway alterations were observed.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a5333754f7abc118adee157https://doi.org/10.1111/jfb.70566
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated Physiological and Transcriptomic Analyses Suggest Key Adaptive Mechanisms of European Perch (Perca fluviatilis) to Acute Heat Stress2026
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  3. 3Multiomics profiling reveals the adaptive responses of largemouth bass to high temperature stress2026 · 5 citations
  4. 4Long-term thermal stress induces hepatic injury and alters the thermotolerance response in Hong Kong catfish (Clarias fuscus)2024 · 30 citations
  5. 5Elucidating the Molecular Basis of Thermal Stress Response in Juvenile Turbot (Scophthalmus maximus) via an Integrative Transcriptome–Metabolome Approach2025 · 2 citations