Key result
CUORE and SCORE2 provide moderate discrimination for 10-year MI or stroke risk in primary care.
Why the study?
The study aimed to externally validate and compare CUORE and SCORE2 for 10-year prediction of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort, and assess the impact of endpoint definitions and recalibration.
How do the CUORE and SCORE2 cardiovascular risk scores compare for 10-year prediction of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort?
Population
38,101 adults in ATS Milan with primary care risk factors linked to registries
Comparison
CUORE vs SCORE2 cardiovascular risk scores
Design
External validation cohort study
Follow-up
10-year
Authors
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Both scores enable moderate discrimination and robust stratification in Italian primary care; leaves open optimal local recalibration and endpoint definitions before threshold-guided decisions.
Cohort (n=38,101)
How do the CUORE and SCORE2 cardiovascular risk scores compare for 10-year prediction of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort?
Effect estimate: AUC 0.730-0.741 (CUORE); AUC 0.713-0.720 (SCORE2)
Both CUORE and SCORE2 provide moderate discrimination for 10-year cardiovascular risk in an Italian primary care cohort, though absolute risk estimates are highly sensitive to administrative endpoint definitions and recalibration strategies.
Milanese et al. (2026) conducted a cohort in Cardiovascular risk (n=38,101). CUORE and SCORE2 risk scores was evaluated on First fatal or non-fatal myocardial infarction or stroke (AUC 0.730-0.741 (CUORE); AUC 0.713-0.720 (SCORE2)). CUORE (AUC 0.730-0.741) and SCORE2 (AUC 0.713-0.720) provided moderate discrimination for 10-year risk of first fatal or non-fatal myocardial infarction or stroke in an Italian primary care cohort.
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