Key result
A low-sodium diet (40 mmol/day) increased the density of atrial natriuretic factor binding sites on platelets compared to a high-sodium diet (10.3 vs 7.1 sites per cell).
Why the study?
Does sodium intake modulate the density of atrial natriuretic factor binding sites on human platelets?
Population
Normal young men (human platelets)
Comparison
Low-sodium diet (40 mmol per day) for 4 days vs High-sodium diet (300 mmol per day) for 4 days
Design
Other, random order
Follow-up
4 days per diet phase
Authors
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May modulate platelet function in hypertension; leaves open physiologic and therapeutic relevance.
RCT
Random order
Does sodium intake modulate the density of atrial natriuretic factor binding sites on human platelets?
Absolute Event Rate: 10.3% vs 7.1%
Human platelets possess specific binding sites for atrial natriuretic factor, and their density is inversely modulated by dietary sodium intake.
Schiffrin et al. (1986) conducted an RCT in Healthy. Low-sodium diet vs. High-sodium diet (300 mmol per day) was evaluated on Binding of atrial natriuretic factor to platelets (sites per cell). A low-sodium diet (40 mmol/day) increased the density of atrial natriuretic factor binding sites on platelets compared to a high-sodium diet (10.3 vs 7.1 sites per cell).
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