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Isolation of sesquiterpene coumarins from Ferula assa-foetida using macroporous resin and molecular dynamics

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Randomized trial investigates the isolation of coumarins in Ferula assa-foetida, indicating effective methods for bioactive compound extraction.

This research aims to isolate bioactive sesquiterpene coumarins from Ferula assa-foetida using macroporous resins, focusing on their pharmacological benefits.
Isolated sesquiterpene coumarins (isosamarcandin and kellerin) from Ferula assa-foetida extract using macroporous resins (A-740, A-750, A-950, LXA-10, HP-20)
Evaluated the adsorption and desorption efficiency of the HP-20 resin for coumarins
Conducted molecular dynamics simulations to assess interaction energies between coumarins and the resin.
HP-20 resin achieved enrichment factors of 4.4 for kellerin and 2.6 for isosamarcandin.
The pseudo-second-order model best fit the experimental adsorption data, with high R² values.
80% aqueous ethanol was optimal for desorption, effectively recovering coumarins while ensuring resin reusability.

Arab-Nezhad et al. (2026) studied this question.

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Randomized trial investigates the isolation of coumarins in Ferula assa-foetida, indicating effective methods for bioactive compound extraction.