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September 17, 2025

Anti-inflammatory Sesquiterpene Coumarins from the Active Fractions of Ferula assa-foetida: In Silico Analysis Endorse Experimental data

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Authors

MAMohammed A. AlamriGSGamal A. SolimanMAMohammed A. Alamri

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Overview

Experimental evaluation demonstrates anti-inflammatory effects of sesquiterpene coumarins in vitro and in vivo, suggesting potential therapeutic applications.

Key Points

  • The study highlights significant anti-inflammatory activity of sesquiterpene coumarins extracted from Ferula assa-foetida.
  • Ethyl acetate and hexane fractions were most effective, with compound 4 showing maximum inhibitory action on nitric oxide generation.
  • Molecular docking and dynamics simulations supported the findings, identifying target genes of the active compounds.
  • No prior reports have described the anti-inflammatory effects of kamolonol, marking a novel contribution to the field.

Cite This Study

Alamri et al. (2025) studied this question.

synapsesocial.com/papers/68d4567431b076d99fa5bcefhttps://doi.org/10.21203/rs.3.rs-7355100/v1
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