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July 13, 2026Singapore Medical JournalOpen Access

Comparative efficacy of common thrombolytics in acute ischaemic stroke: a network meta-analysis

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Authors

KJKew Cheng JoonACAdam Bing Heng ChengRNRui Kyi Ng

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Overview

Network meta-analysis compares thrombolytic efficacy in acute ischaemic stroke, suggesting potential benefits of reteplase.

Key Points

  • This research aims to compare the efficacy of different thrombolytic agents in treating acute ischaemic stroke.
  • Systematic search conducted in PubMed, MEDLINE, Embase, Scopus, and Cochrane Library until August 31, 2024.
  • Twenty-three studies evaluating mortality and modified Rankin Scale in patients with acute ischaemic stroke were included.
  • Comparative efficacy analyzed using a random effects network meta-analysis.
  • No difference in mortality outcomes among thrombolytics (p>0.05).
  • Reteplase showed better functional outcomes compared to alteplase (OR 1.37, 95% CI 1.06, 1.77) and urokinase (OR 1.54, 95% CI 1.14, 2.08).
  • Reteplase had similar functional outcomes compared to alteplase and tenecteplase over a 90-day follow-up.

Cite This Study

Joon et al. (2026) studied this question.

synapsesocial.com/papers/6a548105475c38bf615a5679https://doi.org/10.4103/singaporemedj.smj-2025-179
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