MicroRNAs Add a New Dimension to Cardiovascular Disease
Key result
Targeting microRNAs emerges as a promising therapeutic strategy across various cardiovascular diseases.
Design
Review
Authors
Discussion
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Implication
MicroRNAs play a crucial role in cardiovascular disease pathogenesis and offer a promising new avenue for diagnostic and therapeutic strategies.
Key Points
- To outline the molecular biogenesis, regulatory functions, and target interactions of microRNAs in the cardiovascular system, and to evaluate their potential as therapeutic targets for heart disease.
- Narrative synthesis of experimental and clinical studies investigating microRNA biogenesis, target-recognition mechanisms, and in silico prediction algorithms.
- Evaluation of cardiac microRNA expression profiles, signaling networks, and reactivation of fetal gene programs during pathological cardiac remodeling.
- The 18 most strongly expressed microRNAs and microRNA families account for more than 90% of all microRNA expression in the adult mouse heart, including the let-7 family (about 14%), the miR-30 family (about 5%), and the miR-29 family (about 4%).
- Nearly all of the 18 most enriched cardiac microRNAs demonstrate altered expression during heart disease, coordinating shifts such as the re-expression of fetal gene programs upon cardiac stress.
- Mature microRNAs direct posttranscriptional repression or degradation through seed sequence binding at nucleotides 2 through 8 within the 3'UTR of functionally related messenger RNAs.
PICO
P
Population
Cardiovascular disease
I
Intervention / Comparator
MicroRNAs (miRNAs)
MicroRNAs play a crucial role in cardiovascular disease pathogenesis and offer a promising new avenue for diagnostic and therapeutic strategies.
Cite This Study
Small et al. (2010) conducted a review in Cardiovascular disease. MicroRNAs (miRNAs) was evaluated. MicroRNAs are implicated in the pathogenesis of various cardiovascular diseases and represent a novel target for therapeutic intervention.