Key result
This review summarizes recent findings on PKA-mediated cardiac L-type Ca2+ channel modulation and highlights regulatory mechanisms independent of PKA activity.
Why the study?
Whether protein kinase A modulates cardiac L-type calcium channel open probability by phosphorylation of key residues or via alternative mechanisms remains unclear.
This review highlights emerging mechanisms of cardiac L-type calcium channel regulation, including both PKA-dependent and independent pathways.
Novel cardiac L-type channel mechanisms identified; leaves open clinical translation pending targeted trials.
Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with the channel and is one of the main regulators of its function. Whether this kinase is modulating the channel open probability by phosphorylation of key residues or via alternative mechanisms is unclear. This review summarizes recent findings regarding the PKA-mediated channel modulation and will highlight recently discovered regulatory mechanisms that are independent of PKA activity and involve protein-protein interactions and channel localization.
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Pallien et al. (2020) conducted a review in Cardiac L-type Ca2+ channel regulation. This review summarizes recent findings on PKA-mediated cardiac L-type Ca2+ channel modulation and highlights regulatory mechanisms independent of PKA activity.
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