Key result
Low-flow POTS was associated with a highly attenuated local heating response (60% vs 90% maximum CVC in controls), indicating reduced neuronal nitric oxide bioavailability.
Why the study?
Is cutaneous microvascular neuronal nitric oxide (nNO) impaired in patients with postural tachycardia syndrome (POTS) compared to controls?
Population
Subjects with low flow postural tachycardia syndrome (POTS) and control subjects, aged 22.5 +/- 2 years.
Comparison
Local cutaneous heating and acetylcholine… vs Control subjects without POTS.
Design
Case-control
Authors
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May implicate neuronal nitric oxide deficiency in low-flow POTS; hypothesis-generating and requires prospective validation before clinical consideration.
Case-Control
Is cutaneous microvascular neuronal nitric oxide (nNO) impaired in patients with postural tachycardia syndrome (POTS) compared to controls?
Absolute Event Rate: 60% vs 90%
Cutaneous neuronal nitric oxide activity, but not endothelial nitric oxide, is specifically reduced in patients with low-flow postural tachycardia syndrome.
Stewart et al. (2007) conducted a case-control in Postural tachycardia syndrome (POTS). Low flow postural tachycardia syndrome (POTS) vs. Control subjects was evaluated on Local heating response (percent maximum cutaneous vascular conductance). Low-flow POTS was associated with a highly attenuated local heating response (60% vs 90% maximum CVC in controls), indicating reduced neuronal nitric oxide bioavailability.
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