Why the study?
Does inhibition of nNOS or iNOS restore vasodilative responses to ACh in septic rat skeletal muscle?
Population
Rat hindlimb muscle in a 24-h cecal ligation and perforation (CLP) model of sepsis
Comparison
Pretreatment with iNOS blockers or nNOS… vs Control rats or septic rats without pretreatment
Design
Preclinical
Follow-up
24 hours post-CLP
Authors
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nNOS inhibition may improve microvascular reactivity in experimental sepsis; hypothesis-generating and should not yet change clinical practice.
Does inhibition of nNOS or iNOS restore vasodilative responses to ACh in septic rat skeletal muscle?
Increased endogenous nitric oxide in septic skeletal muscle, likely from upregulated nNOS rather than iNOS, impairs vasodilative responses.
Gocan et al. (2000) studied this question.
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