March 1, 1998Journal of Applied Physiology

Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis

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Population

Rats with sepsis induced by cecal ligation and perforation

Comparison

Local iontophoretic application of vasoactive… vs Control rats

Design

Preclinical

Follow-up

24 hours

Authors

KTKarel TymlWestern University JYJingcheng YuWestern University DMDavid G. McCormackWestern University

Discussion

Member takes

Implication

Hypothesis-generating for iNOS-targeted therapy in sepsis microvascular dysfunction; requires human validation before clinical consideration.

Structured PICO

Population

Rats with sepsis induced by cecal ligation and perforation

Intervention

Local iontophoretic application of vasoactive agents (phenylephrine 10 mM, acetylcholine 10 mM, 5'-N-ethylcarboxamidoadenosine 0.1 mM) and iNOS blocker aminoguanidine (10 mM) on terminal arterioles and downstream daughter capillaries

Comparator

Control rats

Outcome

Changes in arteriolar diameter and red blood cell velocity (VRBC) in response to locally applied vasoactive agentssurrogate

Sepsis impairs capillary and arteriolar responses to vasodilators in skeletal muscle, a dysfunction mediated by inducible nitric oxide synthase (iNOS).

Cite This Study

Tyml et al. (1998) studied this question.

synapsesocial.com/papers/6a6feb48660549caf2c4763c https://doi.org/10.1152/jappl.1998.84.3.837

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Implication

Hypothesis-generating for iNOS-targeted therapy in sepsis microvascular dysfunction; requires human validation before clinical consideration.

Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider