Why the study?
Does hyperdynamic sepsis induced by cecal ligation and perforation alter organ-specific vascular reactivity in rats?
Population
Chronically instrumented rats (n=23)
Comparison
Cecal ligation and perforation to induce… vs Control procedure
Design
Preclinical, randomized
Follow-up
24 hours
Authors
Loading...
May underlie heterogeneous perfusion in experimental sepsis; leaves open translation to human shock.
Does hyperdynamic sepsis induced by cecal ligation and perforation alter organ-specific vascular reactivity in rats?
Hyperdynamic sepsis induces organ-specific depression of vascular smooth muscle contractile responses, particularly in pulmonary and celiac arteries, which may explain regional blood flow redistribution.
Martin et al. (1993) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: