Population
Unanesthetized rats
Design
Preclinical
Authors
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No immediate change to sepsis care; leaves open small-arteriole dilation as a therapeutic target pending human studies.
In a rat model of hyperdynamic sepsis, dilation of small terminal arterioles in skeletal muscle contributes to decreased systemic vascular resistance, highlighting a potential therapeutic target.
Henry M. Cryer (1987) studied this question.
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