Key result
Preoperative symptomatic heart failure was associated with significantly higher perioperative mortality in CABG patients with ventricular dysfunction (7.7% vs 3.5%; OR 2.4, P=0.01).
Why the study?
Preoperative characteristics may influence morbidity and mortality in patients undergoing CABG, leading investigators to examine the impact of symptomatic CHF and angina in patients with ventricular dysfunction.
Does preoperative symptomatic heart failure or reoperation increase perioperative mortality and length of stay in patients with left ventricular dysfunction undergoing CABG?
Population
900 CABG patients with ejection fraction ≤35% and an abnormal signal-averaged ECG
Comparison
Presence and severity of CHF and angina vs absence of symptoms
Design
Retrospective analysis of randomized trial database
Authors
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Preoperative symptomatic HF and reoperation were associated with higher CABG mortality in LV dysfunction; hypothesis-generating for targeted risk stratification.
RCT (n=900)
randomized
Does preoperative symptomatic heart failure or reoperation increase perioperative mortality and length of stay in patients with left ventricular dysfunction undergoing CABG?
Odds Ratio: 2.4
Absolute Event Rate: 7.7% vs 3.5%
p-value: p=0.01
Symptomatic heart failure and reoperation are significant predictors of increased perioperative mortality in patients with severe left ventricular dysfunction undergoing CABG.
Argenziano et al. (1999) conducted an RCT in Left Ventricular Dysfunction undergoing CABG (n=900). Symptomatic congestive heart failure (NYHA class I to IV) vs. No clinical signs of heart failure was evaluated on Perioperative mortality (OR 2.4, p=0.01). Preoperative symptomatic heart failure was associated with significantly higher perioperative mortality in CABG patients with ventricular dysfunction (7.7% vs 3.5%; OR 2.4, P=0.01).
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