Key result
Laboratory assessment of DOAC concentration or activity may be required in some circumstances, challenging the dogma that these agents do not necessitate laboratory testing.
Design
Review
Authors
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May support selective DOAC assay use in complex cases; leaves open assay standardization and outcome validation.
This review highlights that while DOACs generally do not require routine monitoring, laboratory assessment of drug concentration or activity may be necessary in specific clinical circumstances.
Favaloro et al. (2017) conducted a review in Anticoagulation therapy. Laboratory monitoring or measurement of DOACs was evaluated. Laboratory assessment of DOAC concentration or activity may be required in some circumstances, challenging the dogma that these agents do not necessitate laboratory testing.
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