Key result
The chromogenic assay of factor X successfully determined the correct INR in a warfarin-treated patient with dysfibrinogenemia that interfered with standard photo-optical detection.
Why the study?
Does the chromogenic assay of factor X determine the correct INR result in a warfarin-treated patient when standard photo-optical INR testing is inaccurate due to dysfibrinogenemia?
Case Report (n=1)
Does the chromogenic assay of factor X determine the correct INR result in a warfarin-treated patient when standard photo-optical INR testing is inaccurate due to dysfibrinogenemia?
The chromogenic assay of factor X is recommended as an alternative for monitoring warfarin therapy when standard INR testing is inaccurate due to interference with the fibrin endpoint, such as in dysfibrinogenemia.
A warfarin treated patient unexpectedly presented with an elevated international normalized ratio (INR). Repeat testing in two laboratories gave conflicting results. The chromogenic assay of factor X was used to determine the correct INR result. The patient had laboratory results consistent with a dysfibrinogenemia, which prevented detection of the endpoint with a photo-optical detection system. The chromogenic assay of factor X is recommended for monitoring patients on warfarin when the INR cannot be accurately determined due to interference with the fibrin endpoint in the INR.
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Sanfelippo et al. (2009) conducted a case report in Elevated INR during warfarin therapy (n=1). Chromogenic assay of factor X vs. Photo-optical detection system was evaluated on Determination of the correct INR result. The chromogenic assay of factor X successfully determined the correct INR in a warfarin-treated patient with dysfibrinogenemia that interfered with standard photo-optical detection.
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