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July 15, 2026BMC CancerOpen Access

Clinicopathological and follow-up features of coexisting medullary and papillary thyroid cancer

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Authors

CLChuqiao LiuCSCenkai ShenDLDanni Liu

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Overview

Randomized trial investigates distinct characteristics of coexisting thyroid cancers, indicating unique survival outcomes.

Key Points

  • This study aims to explore the clinicopathological and survival features of coexisting medullary and papillary thyroid cancer compared to solitary forms.
  • Included 87 patients with coexisting medullary and papillary thyroid cancer, and compared with 709 solitary medullary and 1,178 solitary papillary thyroid cancer patients.
  • Evaluated biological features and survival outcomes across cohorts using multivariable Cox regression analysis.
  • The MTC–PTC cohort had significantly lower preoperative calcitonin and fewer RET mutations than solitary medullary thyroid cancer (all P < 0.05).
  • Ipsilateral MTC–PTC cases demonstrated the lowest frequency of RET M918T mutations and highest proportion of T1-stage tumors (all P < 0.05).
  • Ipsilateral group identified as an independent predictor of improved structural recurrence-free survival (P < 0.001).

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a57226888b21df87547f6dchttps://doi.org/10.1186/s12885-026-16438-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma2025
  2. 2Analysis of the concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma: A dual center, retrospective study in China2026
  3. 3A Malignant Duo: Mixed Medullary and Follicular Variant Papillary Thyroid Cancer2024 · 2 citations
  4. 4Simultaneous occurrence of papillary thyroid carcinoma, medullary thyroid carcinoma, and lymphoma: A case report2024 · 2 citations
  5. 5Analysis of the clonal origin and differences in the biological behavior of multifocal papillary thyroid carcinoma2024 · 4 citations