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February 19, 2025Journal of Clinical MedicineOpen Access

Simultaneous Medullary and Papillary Thyroid Carcinomas: Personal Experience Report and Literature Review

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Authors

NFNadia De FalcoMAMassimo AgrestiMFMassimo De Falco

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Overview

Case series and literature review reports synchronous medullary and papillary thyroid cancers in autoimmune thyroiditis, highlighting optimal strategies for postoperative management.

Key Points

  • To report institutional observations of synchronous medullary and papillary thyroid carcinomas and synthesize evidence on optimal postoperative therapeutic strategies.
  • Clinical observation and descriptive reporting of cases presenting with concurrent medullary thyroid carcinoma and papillary thyroid carcinoma, including patients with background chronic autoimmune thyroiditis.
  • Targeted literature review assessing post-surgical therapeutic management pathways for synchronous thyroid malignancies.
  • Medullary thyroid carcinoma frequency remains stable at approximately 3% to 5% of all thyroid cancers, contrasting with rising diagnostic rates for papillary thyroid carcinoma.
  • Synchronous occurrence of both distinct histological tumor types was documented in the presence of chronic autoimmune thyroiditis, emphasizing the need for combined postoperative therapeutic algorithms.

Cite This Study

Falco et al. (2025) studied this question.

synapsesocial.com/papers/6aabaafbdec6679171c54119https://doi.org/10.3390/jcm14041382
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis and Pathologic Characteristics of Medullary Thyroid Carcinoma—Review of Current Guidelines2019 · 132 citations
  2. 2Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma2015 · 2,453 citations
  3. 3Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?2023 · 8 citations
  4. 4American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma2022 · 59 citations