Key result
GM-CSF repressed β-chain gene transcription in human mast cells by inducing deacetylation of histones via recruitment of HDACs by the MZF-1/FHL3/NFY complex.
Population
Human mast cell line HMC-1 and human cDNA library
Design
Preclinical
Authors
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Cell-line findings preclude practice change; leaves open GM-CSF-HDAC regulation of mast cell β-chain in vivo.
The study demonstrates that HDACs recruited by the MZF-1/FHL3/NFY complex repress β-chain gene transcription via histone deacetylation in the presence of GM-CSF.
Gradaus et al. (2004) studied this question. GM-CSF was evaluated on β-chain gene expression and acetylation of histones. GM-CSF repressed β-chain gene transcription in human mast cells by inducing deacetylation of histones via recruitment of HDACs by the MZF-1/FHL3/NFY complex.
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