Key result
A coupled-clock system drives the automaticity and generates the pacemaking activity in human sinoatrial nodal pacemaker cells.
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May guide sinoatrial node therapies; leaves open clinical translation of coupled-clock targeting.
The mechanisms that generate pacemaking activity in human sinoatrial nodal cells are revealed.
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Tsutsui et al. (2018) studied this question. A coupled-clock system drives the automaticity and generates the pacemaking activity in human sinoatrial nodal pacemaker cells.
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