Key result
Decreased myocardial miR-19b expression was independently associated with the presence of heart failure in patients with severe aortic stenosis (OR 0.949).
Why the study?
Is miR-19b associated with myocardial collagen cross-linking and LV stiffness in patients with severe aortic stenosis?
Cross-Sectional (n=28)
Yes
Is miR-19b associated with myocardial collagen cross-linking and LV stiffness in patients with severe aortic stenosis?
Odds Ratio: 0.949 (95% CI 0.91–0.99)
p-value: p=<0.05
Serum miR-19b is a potential biomarker for increased myocardial collagen cross-linking and LV stiffness in patients with severe aortic stenosis, particularly those with concurrent heart failure.
miR-19b merits further validation as a fibrosis biomarker in aortic stenosis; does not support practice change.
This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p < 0.05) between serum and myocardium. Compared to controls both myocardial and serum miR-19b were reduced (p < 0.01) in AS patients. In addition, miR-19b was reduced in the myocardium (p < 0.01) and serum (p < 0.05) of patients with HF compared to patients without HF. Myocardial and serum miR-19b were inversely correlated (p < 0.05) with LOX, CCL and LV stiffness in AS patients. In in vitro studies miR-19b inhibition increased (p < 0.05) connective tissue growth factor protein and LOX protein expression in human fibroblasts. In conclusion, decreased miR-19b may be involved in myocardial LOX up-regulation and excessive CCL, and consequently increased LV stiffness in AS patients, namely in those with HF. Serum miR-19b can be a biomarker of these alterations of the myocardial collagen network in AS patients, particularly in patients with HF.
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Beaumont et al. (2017) conducted a cross-sectional in Severe aortic stenosis with or without heart failure (n=28). Myocardial miR-19b expression was evaluated on Presence of heart failure (OR 0.949, 95% CI 0.91-0.99, p=<0.05). Decreased myocardial miR-19b expression was independently associated with the presence of heart failure in patients with severe aortic stenosis (OR 0.949).
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