Key result
Overexpression of the cyclin B1-CDC2 complex re-initiates cell division in adult rat cardiomyocytes, suggesting a potential strategy for myocardial regeneration following injury.
Population
adult rat cardiomyocytes
Design
Preclinical
Authors
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Premature for clinical use in myocardial repair; leaves open cyclin B1-CDC2 targeting to enable adult cardiomyocyte regeneration.
Targeting the cyclin B1-CDC2 complex may offer a strategy to re-initiate cell division in mature cardiomyocytes and facilitate myocardial regeneration following injury.
Bicknell et al. (2004) studied Myocardial injury. Overexpression of the cyclin B1-CDC2 complex was evaluated on Cell division in adult cardiomyocytes. Overexpression of the cyclin B1-CDC2 complex re-initiates cell division in adult rat cardiomyocytes, suggesting a potential strategy for myocardial regeneration following injury.
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