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July 18, 2026BMC Emergency MedicineOpen Access

SVEAT predicts 90-day MACE with ~0.81 AUC, trading lower sensitivity for higher specificity versus HEART and TIMI.

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Why the study?

In emergency department patients presenting with acute chest pain, early identification of those at risk for major adverse cardiac events remains a key challenge.

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

Population

348 patients presenting with acute chest pain

Comparison

SVEAT score vs HEART score vs TIMI score

Follow-up

90 days

Key result

The SVEAT score predicted 90-day MACE with an AUC of 0.806, demonstrating higher specificity (0.86) but lower sensitivity (0.56) compared to the HEART and TIMI scores.

Authors

AAAli AyvazAAAkkan AvcıMTMustafa Oğuz Tuğcan

Discussion

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Overview

SVEAT may aid chest pain triage via higher specificity; hypothesis-generating and should not yet change practice pending validation.

Key Points

  • This study aimed to evaluate the diagnostic performance of the SVEAT score in predicting 90-day major adverse cardiac events (MACE) in patients with acute chest pain.
  • Included 348 patients presenting with acute chest pain
  • Measured high-sensitivity troponin I at admission and 2 hours later
  • Calculated SVEAT, HEART, and TIMI scores, with follow-up for MACE over 90 days.
  • MACE occurred in 7.2% of patients during the 90-day follow-up
  • SVEAT score had the highest AUC of 0.806 compared to HEART (0.756) and TIMI (0.753) scores
  • At a cut-off of 4, the SVEAT score had a sensitivity of 0.56 and specificity of 0.86.

Study Design

Type

Cohort (n=348)

Structured PICO

Does the SVEAT score improve prediction of 90-day MACE compared to HEART and TIMI scores in emergency department patients presenting with acute chest pain?

P
Population
348 patients presenting to the emergency department with acute chest pain, followed for 90 days for the occurrence of major adverse cardiac events.
E
Exposure
SVEAT (Symptoms, Vascular Disease History, Electrocardiography, Age, and Troponin) score
C
Comparator
HEART score and TIMI score
O
Outcome
90-day major adverse cardiac events (MACE)composite

Main Result

Effect estimate: AUC 0.806

The SVEAT score shows higher specificity but lower sensitivity than HEART and TIMI scores for predicting 90-day MACE in ED patients with chest pain, suggesting potential utility as a rule-in rather than a standalone screening tool.

Limitations

  • Relatively low sensitivity limits its utility as a standalone screening tool.
  • relatively low sensitivity, which limits its utility as a standalone screening tool

Cite This Study

Ayvaz et al. (2026) conducted a cohort in Acute chest pain (n=348). SVEAT score vs. HEART and TIMI scores was evaluated on 90-day major adverse cardiac events (MACE) (AUC 0.806). The SVEAT score predicted 90-day MACE with an AUC of 0.806, demonstrating higher specificity (0.86) but lower sensitivity (0.56) compared to the HEART and TIMI scores.

synapsesocial.com/papers/6a5b178d18557b26c2039b2dhttps://doi.org/10.1186/s12873-026-01685-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk Stratification of Acute-Onset Chest Pain: SVEAT Score Versus HEART and TIMI Scores2023 · 8 citations
  2. 2Meta-Analysis of the Diagnostic Accuracy of SVEAT, HEART, and TIMI Scores in Predicting Major Adverse Cardiac Events2026
  3. 3Comparison of SVEAT and HEART scoring in acute chest pain2025
  4. 4SVEAT score outperforms HEART score in patients admitted to a chest pain observation unit2022 · 14 citations
  5. 5SVEAT vs. HEART scores for avoiding unnecessary coronary referrals in ED chest pain patients without cath labs2026