Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure

Figures

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  Figure 1. Patients Flow in This Study Of the 879 patients with heart failure who underwent CPET in the study, 830 were included and stratified into 3 age groups. CPET = cardiopulmonary exercise testing; VE/VCO2 = minute ventilation/carbon dioxide production; VO2 = oxygen consumption.

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  Figure 2. Kaplan-Meier Curves Stratified by Age Groups and Median Peak VO2 or VE/VCO2 Slope Kaplan-Meier curves show that both peak VO2 (top row; high vs low) and VE/VCO2 slope (bottom row; low vs high) were significantly different in the incidence of composite events across age groups (20-64 years: left column, 65-79 years: middle column, 80 years or older: right column). Abbreviations as in Figure 1.

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  Figure 3. Time-Dependent Receiver-Operating Characteristic Curves of Peak Oxygen Consumption or Minute Ventilation/Carbon Dioxide Production Slope by Age Group Time-dependent receiver-operating characteristic curves are shown for composite adverse outcomes of age-stratified (A) peak VO2 and (B) VE/VCO2 slope. Peak VO2 in patients aged 80 years or older had the highest predictive capabilities, whereas VE/VCO2 slope was comparable across age groups. AUC = area under the curve.

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  Central Illustration. Age-Stratified Prognostic Value of CPET in Heart Failure In patients with heart failure, the prognostic value of peak VO2 progressively increased with advancing age and was highest in those aged 80 years or older, whereas VE/VCO2 slope showed comparable prognostic value across age groups. AUC = area under the curve; CPET = cardiopulmonary exercise testing; HF = heart failure; VE/VCO2 = minute ventilation/carbon dioxide production; VO2 = oxygen consumption.