Key result
VE/VCO2 slope > 34 linked to ~169% greater risk of HF hospitalization or CV death.
Why the study?
Heart failure with preserved ejection fraction represents half of heart failure patients, but whether CPET parameters correlate with prognosis in these patients required investigation.
Does a VE/VCO2 slope > 34 on cardiopulmonary exercise testing predict heart failure hospitalizations and cardiovascular death in patients with newly diagnosed heart failure with preserved ejection fraction?
Population
99 outpatients with newly diagnosed HFpEF
Comparison
CPET parameter thresholds (VE/VCO2 slope > 34 vs <= 34 and peakVO2 < 14 mL/min/kg)
Design
Prospective observational cohort study
Follow-up
Median 30 months
Authors
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May aid prognostication in new HFpEF; leaves open prospective validation before clinical use.
Cohort (n=99)
No
Does a VE/VCO2 slope > 34 on cardiopulmonary exercise testing predict heart failure hospitalizations and cardiovascular death in patients with newly diagnosed heart failure with preserved ejection fraction?
Effect estimate: HR 2.69 (95% CI 1.00-7.21)
Absolute Event Rate: 32.2% vs 12.5%
p-value: p=0.04
A VE/VCO2 slope > 34 during cardiopulmonary exercise testing is a significant predictor of heart failure hospitalization and cardiovascular death in patients with newly diagnosed HFpEF.
Conceicao et al. (2025) conducted a cohort in Heart failure with preserved ejection fraction (n=99). VE/VCO2 slope > 34 vs. VE/VCO2 slope ≤ 34 was evaluated on Composite of hospitalization for heart failure or cardiovascular death (HR 2.69, 95% CI 1.00-7.21, p=0.04). A VE/VCO2 slope > 34 was associated with a higher risk of heart failure hospitalization or cardiovascular death compared to a slope ≤ 34 (32.2% vs 12.5%; HR 2.69; 95% CI 1.00-7.21; P=0.04).
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