Key result
VE/VCO2 slope >31 predicts 1-year MACE in ~40% of young HF patients.
Why the study?
Interpreting cardiopulmonary exercise testing results in young, ambulatory heart failure patients is complicated, leaving the prognostic value of CPET parameters in this group unclear.
Does the VE/VCO2 slope predict 1-year major adverse cardiovascular events in young heart failure patients with moderately reduced exercise capacity?
Population
113 young (<50 years) HF patients with LVEF <40% and peak VO2 >12 mL/kg/min
Comparison
Prognostic evaluation across CPET parameters
Design
Single-center retrospective observational study
Follow-up
1 year
Authors
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May prompt early advanced therapy referral in young HF; extends VE/VCO2 slope utility to moderate exercise impairment.
Does the VE/VCO2 slope predict 1-year major adverse cardiovascular events in young heart failure patients with moderately reduced exercise capacity?
In young heart failure patients with moderately reduced exercise capacity, a VE/VCO2 slope >31 is a strong independent predictor of 1-year MACE and may help identify patients needing early referral for advanced therapies like LVAD or heart transplantation.
Komeyama et al. (2026) studied this question. A VE/VCO2 slope over 31 optimally predicted one-year major adverse cardiovascular events, occurring in 39.8% of young heart failure patients with moderately reduced exercise capacity.
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