Key result
A biomechanics-based approach to predicting abdominal aortic aneurysm rupture on a patient-specific basis may ultimately prove superior to the widely used maximum diameter criterion.
Why the study?
Does a biomechanics-based approach improve the prediction of AAA rupture compared to the maximum diameter criterion in patients with abdominal aortic aneurysm?
Does a biomechanics-based approach improve the prediction of AAA rupture compared to the maximum diameter criterion in patients with abdominal aortic aneurysm?
Biomechanical evaluation of AAA wall stress and weakening may provide a superior, patient-specific method for predicting rupture risk compared to traditional maximum diameter criteria.
Biomechanics-based AAA rupture prediction should not yet replace diameter criteria in practice; leaves open need for prospective validation.
Rupture of abdominal aortic aneurysm (AAA) represents a significant clinical event, having a mortality rate of 90% and being currently ranked as the 13th leading cause of death in the US. The ability to reliably evaluate the susceptibility of a particular AAA to rupture on a case-specific basis could vastly improve the clinical management of these patients. Because AAA rupture represents a mechanical failure of the degenerated aortic wall, biomechanical considerations are important to understand this process and to improve our predictions of its occurrence. Presented here is an overview of research to date related to the biomechanics of AAA rupture. This includes a summary of results related to ex vivo and in vivo mechanical testing, noninvasive AAA wall stress estimations, and potential mechanisms of AAA wall weakening. We conclude with a demonstration of a biomechanics-based approach to predicting AAA rupture on a patient-specific basis, which may ultimately prove to be superior to the widely and currently used maximum diameter criterion.
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Vorp et al. (2005) conducted a review in Abdominal aortic aneurysm (AAA) rupture. Biomechanics-based approach to predicting AAA rupture vs. Maximum diameter criterion was evaluated. A biomechanics-based approach to predicting abdominal aortic aneurysm rupture on a patient-specific basis may ultimately prove superior to the widely used maximum diameter criterion.
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