Key result
Biological, geometric, and biomechanical factors correlate with abdominal aortic aneurysm rupture risk with higher accuracy and sensitivity than maximum diameter alone.
Geometric and biomechanical factors may predict abdominal aortic aneurysm rupture risk with higher accuracy and sensitivity than the traditional reliance on maximum diameter alone.
May refine AAA rupture prediction beyond diameter alone; leaves open prospective validation before clinical adoption.
The current clinical management of abdominal aortic aneurysm (AAA) disease is based to a great extent on measuring the aneurysm maximum diameter to decide when timely intervention is required. Decades of clinical evidence show that aneurysm diameter is positively associated with the probability of rupture, but that other parameters may also play a role in causing or predisposing the AAA to rupture. Biological factors associated with smooth muscle apoptosis are implicated in AAA expansion while geometric and biomechanical factors identified by means of computational modeling techniques have been positively correlated with rupture risk with a higher accuracy and sensitivity than maximum diameter alone. The objective of this review is to examine the factors found to influence AAA disease progression, clinical management and rupture, as well as a patent review that highlights developments in this arena in the past few years.
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Raut et al. (2013) conducted a review in Abdominal aortic aneurysm. Biological, geometric and biomechanical factors vs. Maximum diameter alone was evaluated on Abdominal aortic aneurysm rupture risk. Biological, geometric, and biomechanical factors correlate with abdominal aortic aneurysm rupture risk with higher accuracy and sensitivity than maximum diameter alone.
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