Key result
Inducible expression of Ang2 in mice promoted regression of ocular neovascularization when the Ang2/VEGF ratio was high, but stimulated neovascularization in the setting of hypoxia or high VEGF.
Why the study?
Does inducible expression of Ang2 affect retinal and choroidal circulations and ocular neovascularization in transgenic mice?
Population
Double and triple transgenic mice with inducible expression of angiopoietin-2 and models of ocular…
Design
Preclinical
Authors
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Ang2 overexpression spares mature retinal vessels in mice; leaves open its context-specific role in ocular neovascularization.
Does inducible expression of Ang2 affect retinal and choroidal circulations and ocular neovascularization in transgenic mice?
Angiopoietin-2 has context-dependent effects on ocular neovascularization, promoting regression when the Ang2/VEGF ratio is high, but stimulating it in the presence of hypoxia or high VEGF.
Oshima et al. (2005) studied Ocular neovascularization. Inducible expression of angiopoietin-2 (Ang2) was evaluated on Retinal and choroidal neovascularization. Inducible expression of Ang2 in mice promoted regression of ocular neovascularization when the Ang2/VEGF ratio was high, but stimulated neovascularization in the setting of hypoxia or high VEGF.
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