Key result
Chronic systemic delivery of angiopoietin-2 in transgenic mice induced angiogenesis and promoted myocardial coronary vessel remodeling in the absence of increased VEGF expression.
Chronic systemic delivery of angiopoietin-2 induces angiogenesis and myocardial coronary vessel remodeling independently of VEGF expression in a transgenic mouse model.
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Angiopoietin-2 may drive VEGF-independent coronary angiogenesis in mice; hypothesis-generating for remodeling therapies pending larger studies.
Angiopoietin-2 has been implicated in the angiogenic response; however, this response has been tied to the expression of VEGF, and an independent angiogenic role has yet to be described. In this report, we detail the generation of transgenic mice that conditionally express angiopoietin-2 in the liver, resulting in sustained increases in circulating levels. These animals survive gestation and present with several vascular abnormalities, including an increase in the diameter of myocardial coronary vessels and a reduction in the density of endocardial vessels. In the lung, prominent increases in vessel diameter were observed. These vascular remodeling changes occurred in the absence of any apparent increase in VEGF expression. Our results illustrate that chronic systemic delivery of angiopoietin-2 induces angiogenesis in the absence of increased VEGF expression and that angiopoietin-2 promotes myocardial coronary vessel remodeling.
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Bureau et al. (2006) studied this question. Chronic systemic delivery of angiopoietin-2 was evaluated on Vascular remodeling and angiogenesis. Chronic systemic delivery of angiopoietin-2 in transgenic mice induced angiogenesis and promoted myocardial coronary vessel remodeling in the absence of increased VEGF expression.
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