What question did this study set out to answer?

The aim is to investigate the role of angiopoietin-1 in vascularization and remodeling in transgenic mice.

October 16, 1998Science

Increased Vascularization in Mice Overexpressing Angiopoietin-1

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Mouse overexpression data warrant no clinical change; leaves open human translation of angiopoietin-1 for therapeutic angiogenesis.

The aim is to investigate the role of angiopoietin-1 in vascularization and remodeling in transgenic mice.
Transgenic mice were created to overexpress angiopoietin-1 in the skin.
Vascular structures were analyzed for size, number, and branching in the skin.
Comparison made between normal and angiopoietin-1 overexpressing mice.
Mice overexpressing angiopoietin-1 displayed larger and more numerous blood vessels.
Vascular structures in these mice showed a higher degree of branching.
Findings suggest potential for using angiopoietins to enhance therapeutic angiogenesis.

Suri et al. (1998) studied this question.

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