Key result
Angiopoietin-1 overexpression stabilized breast cancer xenograft neovasculature, significantly increasing the smooth muscle-to-endothelial cell ratio (2.17 vs 0.81, p<0.01) and reducing tumour growth.
Population
Breast cancer xenograft models and cultured vascular smooth muscle and endothelial cells
Design
Preclinical
Authors
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May support vascular normalization strategies in breast cancer models; leaves open clinical translation pending human studies.
Absolute Event Rate: 2.17% vs 0.81%
p-value: p=<0.01
Angiopoietin-1 overexpression inhibits breast cancer xenograft tumour growth by stabilizing tumour neovasculature and decreasing cancer cell proliferation and apoptosis.
Tian et al. (2002) studied Breast cancer xenograft tumour. Angiopoietin-1 overexpression vs. Vector-transfected control cells was evaluated on Smooth muscle-to-endothelial cell (SM/EC) ratio (p=<0.01). Angiopoietin-1 overexpression stabilized breast cancer xenograft neovasculature, significantly increasing the smooth muscle-to-endothelial cell ratio (2.17 vs 0.81, p<0.01) and reducing tumour growth.
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